Tet38 Efflux Pump Contributes to Fosfomycin Resistance in Staphylococcus aureus

Antimicrob Agents Chemother. 2018 Jul 27;62(8):e00927-18. doi: 10.1128/AAC.00927-18. Print 2018 Aug.

Abstract

Fosfomycin inhibits MurA following uptake by the GlpT transporter of glycerol-3-phosphate in Escherichia coli In Staphylococcus aureus, plasmid overexpression of the Tet38 efflux pump and a glpT mutant resulted in increased MICs and decreased accumulation of fosfomycin, with MICs affected by glycerol-3-phosphate. In contrast, a tet38 mutant had a lower MIC and increased accumulation of fosfomycin, suggesting that Tet38 acts as an efflux transporter of fosfomycin.

Keywords: G3P; S. aureus; Tet38; efflux pump; fosfomycin.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Drug Resistance, Bacterial
  • Fosfomycin / metabolism*
  • Fosfomycin / pharmacology*
  • Microbial Sensitivity Tests
  • Staphylococcus aureus / drug effects*
  • Staphylococcus aureus / metabolism

Substances

  • Fosfomycin