A case of acute myeloid leukemia with promyelocytic features characterized by expression of a novel RARG- CPSF6 fusion

Blood Adv. 2018 Jun 12;2(11):1295-1299. doi: 10.1182/bloodadvances.2017014183.

Abstract

  1. Novel RARG-CPSF6 fusion in an AML case with promyelocytic features and no evidence of PML-RARA or X-RARA fusion.

  2. Gene fusions involving RARG can initiate AML with promyelocytic morphological features.

Publication types

  • Case Reports
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Chromosomes, Human, Pair 15 / genetics
  • Chromosomes, Human, Pair 15 / metabolism
  • Chromosomes, Human, Pair 17 / genetics
  • Chromosomes, Human, Pair 17 / metabolism
  • Gene Expression Regulation, Leukemic*
  • Humans
  • Leukemia, Promyelocytic, Acute* / genetics
  • Leukemia, Promyelocytic, Acute* / metabolism
  • Leukemia, Promyelocytic, Acute* / pathology
  • Male
  • Oncogene Proteins, Fusion* / biosynthesis
  • Oncogene Proteins, Fusion* / genetics
  • PPAR gamma* / biosynthesis
  • PPAR gamma* / genetics
  • Translocation, Genetic
  • mRNA Cleavage and Polyadenylation Factors* / biosynthesis
  • mRNA Cleavage and Polyadenylation Factors* / genetics

Substances

  • Oncogene Proteins, Fusion
  • PPAR gamma
  • PPARG protein, human
  • cleavage factor Im, human
  • mRNA Cleavage and Polyadenylation Factors