Embryonic senescent cells re-enter cell cycle and contribute to tissues after birth

Yi Li; Huan Zhao; Xiuzhen Huang; Juan Tang; Shaohua Zhang; Yan Li; Xiuxiu Liu; Lingjuan He; Zhengyu Ju; Kathy O Lui; Bin Zhou

doi:10.1038/s41422-018-0050-6

Embryonic senescent cells re-enter cell cycle and contribute to tissues after birth

Cell Res. 2018 Jul;28(7):775-778. doi: 10.1038/s41422-018-0050-6. Epub 2018 Jun 5.

Authors

Yi Li^{1

2}, Huan Zhao^{1

2}, Xiuzhen Huang^{1

2}, Juan Tang^{1

2}, Shaohua Zhang¹, Yan Li^{1

2}, Xiuxiu Liu¹, Lingjuan He^{1

2}, Zhengyu Ju³, Kathy O Lui⁴, Bin Zhou^{5

6

7

8}

Affiliations

¹ State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
² Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
³ Key Laboratory of Regenerative Medicine of Ministry of Education, Institute of Aging and Regenerative Medicine, Jinan University, Guangzhou, Guangdong, 510632, China.
⁴ Department of Chemical Pathology, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong SAR, China.
⁵ State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China. zhoubin@sibs.ac.cn.
⁶ Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China. zhoubin@sibs.ac.cn.
⁷ Key Laboratory of Regenerative Medicine of Ministry of Education, Institute of Aging and Regenerative Medicine, Jinan University, Guangzhou, Guangdong, 510632, China. zhoubin@sibs.ac.cn.
⁸ School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. zhoubin@sibs.ac.cn.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Cycle*
Cells, Cultured
Cellular Senescence*
Cyclin-Dependent Kinase Inhibitor p21 / genetics
Embryo, Mammalian / cytology*
Mice
Mutation
beta-Galactosidase / analysis

Substances

Cdkn1a protein, mouse
Cyclin-Dependent Kinase Inhibitor p21
beta-Galactosidase