Quantitative imaging of brain energy metabolisms and neuroenergetics using in vivo X-nuclear 2H, 17O and 31P MRS at ultra-high field

Abstract

Brain energy metabolism relies predominantly on glucose and oxygen utilization to generate biochemical energy in the form of adenosine triphosphate (ATP). ATP is essential for maintaining basal electrophysiological activities in a resting brain and supporting evoked neuronal activity under an activated state. Studying complex neuroenergetic processes in the brain requires sophisticated neuroimaging techniques enabling noninvasive and quantitative assessment of cerebral energy metabolisms and quantification of metabolic rates. Recent state-of-the-art in vivo X-nuclear MRS techniques, including ²H, ¹⁷O and ³¹P MRS have shown promise, especially at ultra-high fields, in the quest for understanding neuroenergetics and brain function using preclinical models and in human subjects under healthy and diseased conditions.

Keywords: Brain energy metabolism; Cerebral metabolic rate of glucose (CMR(Glc)) and oxygen (CMRO(2)) consumption, and ATP production (CMR(ATP)); In vivo X-nuclear MRS and imaging; NAD redox state; Neuroenergetics; TCA cycle rate (V(TCA)); Ultra-high magnetic field (UHF).