Interspecies chimeras

Fabian Suchy; Hiromitsu Nakauchi

doi:10.1016/j.gde.2018.05.007

Interspecies chimeras

Curr Opin Genet Dev. 2018 Oct:52:36-41. doi: 10.1016/j.gde.2018.05.007. Epub 2018 May 30.

Authors

Fabian Suchy¹, Hiromitsu Nakauchi²

Affiliations

¹ Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, United States.
² Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, United States; Division of Stem Cell Therapy, Institute of Medical Science, University of Tokyo, Tokyo 108-0071, Japan. Electronic address: nakauchi@stanford.edu.

PMID: 29859382
DOI: 10.1016/j.gde.2018.05.007

Abstract

By probing early embryogenesis and regeneration, interspecies chimeras provide a unique platform for discovery and clinical use. Although efficient generation of human:animal chimeric embryos remains elusive, recent advancements attempt to overcome incompatibilities in xenogeneic development and transplantation.

Publication types

Review

MeSH terms

Animals
Chimera / genetics*
Chimera / growth & development
Embryonic Development / genetics*
Humans
Pluripotent Stem Cells*
Species Specificity