Aim: Our research evaluated the ability of contrast-enhanced ultrasound (CEUS) and contrast enhanced computer tomography (CECT), performed 48 h after radiofrequency ablation (RFA), to detect residual tumor tissue. As recently published studies have evaluated periprocedural CEUS performed within 24 h after procedure and their results were not satisfactory, it seems that postponing the control test by one day could increase the sensitivity of both methods.
Patients and methods: We evaluated 33 patients with 37 lesions, who met the criteria for our study. The criteria were 1) the treated lesion is sonographically viewable and 2) the patient underwent both CEUS and CECT control 48 h after treatment and additional follow-up 3 months later by CECT. Presence of residual tumor tissue and the size of necrosis were recorded and compared to the results of 3-months CECT.
Results: Nine residues were present in our group. CEUS and CECT showed similar sensitivity (66.7% and 77.8%, respectively) and identical specificity (both 96.4%) for detection of residual tumor tissue. CEUS significantly underestimated the size of necrosis in comparison to CECT (on average by 2.4 mm, P=0.0005). Over the 3-months follow-up period the size of necrosis decreased in all patients (on average by 7.2 mm, P<0.0001).
Conclusion: The quality of tumor residue detection in 48-h CEUS was comparable to that of 48-h CECT. This finding suggests the CEUS being a feasible substitute for CECT. Both methods show reasonable sensitivity; therefore this timing seems to be appropriate for the first post-treatment control while also allowing for early retreatment if residual tumor tissue is found.