CCR7 fuels and LFA-1 grips

Patrick W Oakes; Deborah J Fowell

doi:10.1038/s41590-018-0118-y

CCR7 fuels and LFA-1 grips

Nat Immunol. 2018 Jun;19(6):516-518. doi: 10.1038/s41590-018-0118-y.

Authors

Patrick W Oakes¹, Deborah J Fowell²

Affiliations

¹ Department of Physics and Astronomy and Department of Biology, University of Rochester, Rochester, NY, USA.
² David H. Smith Center for Vaccine Biology and immunology, Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, USA. deborah_fowell@urmc.rochester.edu.

Abstract

Naïve T cells migrate rapidly through the lymph node. A high-resolution look at the chemokine receptor CCR7 and integrin LFA-1 reveals T cells remain highly responsive to their microenvironment by instantaneous tuning of chemokine-regulated actin flow and integrin-regulated adhesion.

Publication types

Comment

MeSH terms

Actins
Chemokines
Friction
Lymphocyte Function-Associated Antigen-1*
T-Lymphocytes*

Substances

Actins
Chemokines
Lymphocyte Function-Associated Antigen-1

Abstract

Publication types

MeSH terms

Substances

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