To aggressively proliferate and metastasize, cancer cells are in extreme need of energy supply and nutrients. Therefore, a promising cancer therapy strategy is developed to target its hallmark feature of metabolism. Recent findings revealed the regulatory role of caveolin-1 (Cav-1), a structural protein of caveolae, in cancer metabolism. And low Cav-1 expression in tumor stroma was proved to be a central player of cancer malignant phenotype. Here, we summarized the progressions of studies on Cav-1, mitochondria and cancer metabolism to indicate that the altered metabolism induced by Cav-1 and mitochondria association is a major cause of cancer malignant phenotype.
癌细胞快速增殖并转移，会消耗大量能量和营养物质，因而发展靶向于癌细胞独特能量代谢方式的治疗手段有望实现癌症的有效治愈。近年来多篇文献报道了细胞膜上特化小窝结构的功能蛋白小窝蛋白-1（Cav-1）对癌细胞能量代谢具有关键调节作用，并指出肿瘤基质细胞中的 Cav-1 低表达可诱导癌细胞恶性表型。本文综述了近期关于 Cav-1 与线粒体功能、细胞能量代谢之间相互作用的研究进展，并指出 Cav-1 与线粒体之间的相互作用可能是癌症能量代谢转换所引起的恶性表型的基础。.
Keywords: caveolin-1; malignant phenotype; metabolism; mitochondria; reactive oxygen species.