A Review: The Bioactivities and Pharmacological Applications of Polygonatum sibiricum polysaccharides

Molecules. 2018 May 14;23(5):1170. doi: 10.3390/molecules23051170.

Abstract

Traditional Chinese Medicine (TCM) has been widely used in China and is regarded as the most important therapeutic. Polygonatum sibiricum (PS), a natural plant used in traditional Chinese medicine, has various functions associated with a number of its components. There are many compositions in PS including polysaccharides, steroids, anthraquinone, alkaloids, cardiac glycosides, lignin, vitamins, various acids, and so on. Of these, polysaccharides play a significant role in PS-based therapeutics. This article summarizes Polygonatum sibiricum polysaccharides (PSP) have many pharmacological applications and biological activities, such as their antioxidant activity, anti-aging activity, an anti-fatigue effect, immunity enhancement effect, antibacterial effect, anti-inflammatory effect, hypolipidemic and antiatherosclerotic effects, anti-osteoporosis effect, liver protection, treatment of diabetes mellitus (DM), anti-cancer effect, and may help prevent Alzheimer's disease, and so on. This review summarized the extraction method, purification method, compositions, pharmacological applications, biological activities, biosynthesis, and prospects of PSP, providing a basis for further study of PS and PSP.

Keywords: Polygonatum sibiricum polysaccharides (PSP); biological activity; biosythesis; compositions; pharmacological applications; prospects.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemistry
  • Anti-Bacterial Agents / pharmacology
  • Antioxidants / chemistry
  • Antioxidants / pharmacology
  • Drugs, Chinese Herbal / chemistry*
  • Drugs, Chinese Herbal / pharmacology*
  • Drugs, Chinese Herbal / therapeutic use
  • Humans
  • Immunologic Factors / chemistry
  • Immunologic Factors / pharmacology
  • Medicine, Chinese Traditional
  • Mice
  • Phytochemicals / chemistry
  • Phytochemicals / pharmacology
  • Polygonatum / chemistry*
  • Polysaccharides / biosynthesis
  • Polysaccharides / chemistry*
  • Polysaccharides / pharmacology*
  • Polysaccharides / therapeutic use

Substances

  • Anti-Bacterial Agents
  • Antioxidants
  • Drugs, Chinese Herbal
  • Immunologic Factors
  • Phytochemicals
  • Polysaccharides