Noninvasive Measurement of Sciatic Nerve Stiffness in Patients With Chronic Low Back Related Leg Pain Using Shear Wave Elastography

J Ultrasound Med. 2019 Jan;38(1):157-164. doi: 10.1002/jum.14679. Epub 2018 May 6.

Abstract

Objectives: The purpose of this study was to determine whether sciatic nerve stiffness is altered in people with chronic low back-related leg pain by using shear wave elastography.

Methods: In this cross-sectional study, the sciatic nerve shear wave velocity (ie, an index of stiffness) was measured in both legs of 16 participants (8 with unilateral low back-related leg pain and 8 healthy controls). Sciatic stiffness was measured during a passive ankle dorsiflexion motion performed at 2°/s in an isokinetic dynamometer. The ankle range of motion and passive torque, as well as muscle activity, were also measured.

Results: In people with low back-related leg pain, the affected limb showed higher sciatic nerve stiffness compared to the unaffected limb (+11.3%; P = .05). However, no differences were observed between the unaffected limb of people with low back-related leg pain and the healthy controls (P = .34).

Conclusions: People with chronic low back-related leg pain have interlimb differences in sciatic nerve stiffness, as measured by a safe and noninvasive method: shear wave elastography. The changes found may be related to alterations in nerve mechanical properties, which should be confirmed by future investigations.

Keywords: low back-related leg pain; musculoskeletal; nerve biomechanics; peripheral nerve; sciatica; shear wave velocity.

MeSH terms

  • Adolescent
  • Adult
  • Chronic Pain / etiology
  • Chronic Pain / physiopathology
  • Cross-Sectional Studies
  • Elasticity Imaging Techniques / methods*
  • Electromyography
  • Female
  • Humans
  • Leg / physiopathology
  • Low Back Pain / etiology*
  • Low Back Pain / physiopathology
  • Male
  • Middle Aged
  • Sciatic Nerve / diagnostic imaging*
  • Sciatic Nerve / pathology*
  • Sciatic Neuropathy / diagnostic imaging*
  • Sciatic Neuropathy / pathology*
  • Young Adult