1 Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT 84112, USA.
2 Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, UT 84112, USA. Electronic address: scott.a.summers@health.utah.edu.
Chaurasia and colleagues discuss the provocative new finding that some enzymes in the de novo sphingolipid synthesis pathway have dual roles as transcriptional regulators.