Microsatellite instability associated with durable complete response to PD-L1 inhibitor in head and neck squamous cell carcinoma

Magalie P Tardy; Ilaria Di Mauro; Nathalie Ebran; Sadal Refae; Alexandre Bozec; Karen Benezery; Frédéric Peyrade; Joel Guigay; Anne Sudaka-Bahadoran; Cécile Badoual; Florence Pedeutour; Esma Saada-Bouzid

doi:10.1016/j.oraloncology.2018.04.001

Microsatellite instability associated with durable complete response to PD-L1 inhibitor in head and neck squamous cell carcinoma

Oral Oncol. 2018 May:80:104-107. doi: 10.1016/j.oraloncology.2018.04.001. Epub 2018 Apr 7.

Authors

Affiliations

¹ Department of Medical Oncology, Centre Antoine Lacassagne, Cancer Research Center, 33 avenue de Valombrose, 06189 Nice cedex 2, France.
² Laboratory of Solid Tumor Genetics, University Hospital of Nice-Côte d'Azur, 30 avenue de la Voie romaine, 06001 Nice, France; Institute for Research on Cancer and Aging (IRCAN), CNRS, UMR 7284/INSERM U1081, Nice, France.
³ Oncopharmacology Unit, Centre Antoine Lacassagne, Cancer Research Center, 33 avenue de Valombrose, 06189 Nice cedex 2, France.
⁴ Department of Medical Oncology, Centre Antoine Lacassagne, Cancer Research Center, 33 avenue de Valombrose, 06189 Nice cedex 2, France; Oncopharmacology Unit, Centre Antoine Lacassagne, Cancer Research Center, 33 avenue de Valombrose, 06189 Nice cedex 2, France.
⁵ Institut universitaire de la face et du cou, 31 avenue de Valombrose, 06189 Nice cedex 2, France.
⁶ Department of Radiotherapy, Centre Antoine Lacassagne, Cancer Research Center, 33 avenue de Valombrose, 06189 Nice cedex 2, France.
⁷ Department of Pathology, Centre Antoine Lacassagne, Cancer Research Center, 33 avenue de Valombrose, 06189 Nice cedex 2, France.
⁸ Department of Pathology, G. Pompidou European Hospital APHP-University Paris Descartes, Paris, France.
⁹ Department of Medical Oncology, Centre Antoine Lacassagne, Cancer Research Center, 33 avenue de Valombrose, 06189 Nice cedex 2, France; Oncopharmacology Unit, Centre Antoine Lacassagne, Cancer Research Center, 33 avenue de Valombrose, 06189 Nice cedex 2, France. Electronic address: esma.saada-bouzid@nice.unicancer.fr.

PMID: 29631799
DOI: 10.1016/j.oraloncology.2018.04.001

No abstract available

Publication types

Case Reports
Letter

MeSH terms

Antineoplastic Agents / pharmacology
Antineoplastic Agents / therapeutic use*
B7-H1 Antigen / antagonists & inhibitors*
Head and Neck Neoplasms / drug therapy*
Head and Neck Neoplasms / genetics*
Humans
Male
Microsatellite Instability*
Middle Aged
Squamous Cell Carcinoma of Head and Neck / drug therapy*
Squamous Cell Carcinoma of Head and Neck / genetics*
Treatment Outcome

Substances

Antineoplastic Agents
B7-H1 Antigen
CD274 protein, human