Intravascular Ultrasound Studies of Plaque Progression and Regression: Impact of Lipid-Modifying Therapies

Daisuke Shishikura; Satoshi Honda; Jordan Andrews; Stephen J Nicholls

doi:10.1016/j.ccl.2017.12.014

Intravascular Ultrasound Studies of Plaque Progression and Regression: Impact of Lipid-Modifying Therapies

Cardiol Clin. 2018 May;36(2):329-334. doi: 10.1016/j.ccl.2017.12.014. Epub 2018 Feb 21.

Authors

Daisuke Shishikura¹, Satoshi Honda¹, Jordan Andrews¹, Stephen J Nicholls²

Affiliations

¹ South Australian Health and Medical Research Institute, University of Adelaide, PO Box 11060, Adelaide, SA 5001, Australia.
² South Australian Health and Medical Research Institute, University of Adelaide, PO Box 11060, Adelaide, SA 5001, Australia. Electronic address: stephen.nicholls@sahmri.com.

PMID: 29609762
DOI: 10.1016/j.ccl.2017.12.014

Abstract

Application of serial intravascular ultrasound imaging within the coronary arteries enables characterization of the factors associated with progression of atherosclerotic plaque. Integration into clinical trials has enabled determination of the impact of medical therapies on coronary disease. These trials have provided important insights into the effects of lipid-modifying agents currently used in clinical practice and of experimental agents at early stages of clinical development. The results of these trials are reviewed.

Keywords: Atherosclerosis; Clinical trials; Intravascular ultrasound; Lipids.

Publication types

Review

MeSH terms

Coronary Artery Disease* / blood
Coronary Artery Disease* / diagnosis
Coronary Artery Disease* / drug therapy
Coronary Vessels / diagnostic imaging*
Disease Progression
Humans
Hypolipidemic Agents / therapeutic use*
Lipids / blood
Plaque, Atherosclerotic* / blood
Plaque, Atherosclerotic* / diagnosis
Plaque, Atherosclerotic* / drug therapy
Ultrasonography, Interventional / methods*

Substances

Hypolipidemic Agents
Lipids