Pegylated interferon Alfa-2a and hydroxyurea in polycythemia vera and essential thrombocythemia: differential cellular and molecular responses

Leukemia. 2018 Aug;32(8):1830-1833. doi: 10.1038/s41375-018-0080-6. Epub 2018 Feb 28.
No abstract available

MeSH terms

  • Antineoplastic Agents / pharmacology*
  • Antiviral Agents / pharmacology*
  • Humans
  • Hydroxyurea / pharmacology*
  • Interferon-alpha / pharmacology*
  • Janus Kinase 2 / genetics*
  • Mutation
  • Polycythemia Vera / drug therapy
  • Polycythemia Vera / genetics
  • Polycythemia Vera / pathology*
  • Polyethylene Glycols / pharmacology*
  • Prognosis
  • Recombinant Proteins / pharmacology
  • Thrombocythemia, Essential / drug therapy
  • Thrombocythemia, Essential / metabolism
  • Thrombocythemia, Essential / pathology*
  • Tumor Cells, Cultured

Substances

  • Antineoplastic Agents
  • Antiviral Agents
  • Interferon-alpha
  • Recombinant Proteins
  • Polyethylene Glycols
  • JAK2 protein, human
  • Janus Kinase 2
  • peginterferon alfa-2a
  • Hydroxyurea