Engineering Human Bone Marrow Proxies

Paul E Bourgine; Ivan Martin; Timm Schroeder

doi:10.1016/j.stem.2018.01.002

Engineering Human Bone Marrow Proxies

Cell Stem Cell. 2018 Mar 1;22(3):298-301. doi: 10.1016/j.stem.2018.01.002.

Authors

Paul E Bourgine¹, Ivan Martin², Timm Schroeder³

Affiliations

¹ Department of Biosystems Science and Engineering, ETH Zurich, CH-4058 Basel, Switzerland; Tissue Engineering, Department of Biomedicine, University of Basel and University Hospital Basel, CH-4056 Basel, Switzerland.
² Tissue Engineering, Department of Biomedicine, University of Basel and University Hospital Basel, CH-4056 Basel, Switzerland.
³ Department of Biosystems Science and Engineering, ETH Zurich, CH-4058 Basel, Switzerland. Electronic address: timm.schroeder@bsse.ethz.ch.

PMID: 29499148
DOI: 10.1016/j.stem.2018.01.002

Abstract

Recent advances in engineering complex organs in vitro inspire the development of human bone marrow equivalents to foster scientific discovery and innovative therapeutics. Here, we discuss challenges in generating relevant human bone marrow proxies, potential design principles, and future directions.

Publication types

Review

MeSH terms

Bone Marrow / physiology*
Cell Culture Techniques
Hematopoiesis
Humans
Models, Biological
Tissue Engineering / methods*