Interim effectiveness of trivalent influenza vaccine in a season dominated by lineage mismatched influenza B, northern Spain, 2017/18

Euro Surveill. 2018 Feb;23(7):18-00057. doi: 10.2807/1560-7917.ES.2018.23.7.18-00057.

Abstract

The 2017/18 interim estimate of trivalent influenza vaccine effectiveness (VE) was 39% (95% confidence interval: 20-54) in Navarre. Compared with individuals unvaccinated in the current and five previous seasons, VE against influenza B was 41% for current and any prior doses, 67% for current vaccination only, and 22% for any prior doses, and 43%, 51% and 54%, respectively against influenza A(H3N2). This suggests moderate VE despite predominance of lineage mismatched influenza B.

Keywords: case-control study; influenza; influenza vaccine; influenza-like illness; repeated vaccination; vaccine effectiveness.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Influenza A Virus, H3N2 Subtype / immunology
  • Influenza A Virus, H3N2 Subtype / isolation & purification*
  • Influenza B virus / immunology
  • Influenza B virus / isolation & purification*
  • Influenza Vaccines / administration & dosage*
  • Influenza Vaccines / immunology
  • Influenza, Human / epidemiology
  • Influenza, Human / prevention & control*
  • Male
  • Middle Aged
  • Seasons*
  • Sentinel Surveillance*
  • Spain / epidemiology
  • Vaccination / statistics & numerical data*
  • Young Adult

Substances

  • Influenza Vaccines