Low-level TP53 mutational load antecedes clonal expansion in chronic lymphocytic leukaemia

Br J Haematol. 2019 Feb;184(4):657-659. doi: 10.1111/bjh.15147. Epub 2018 Feb 20.

Authors

Affiliations

¹ Genetica Medica, Azienda Ospedaliera Universitaria Senese, Siena, Italy.
² Medical Genetics, University of Siena, Siena, Italy.
³ IRCCS MultiMedica, Milan, Italy.
⁴ Department of Medicine and Immunological Sciences, Haematology Unit, Azienda Ospedaliera Universitaria Senese and University of Siena, Siena, Italy.

PMID: 29460960
DOI: 10.1111/bjh.15147

No abstract available

Keywords: CLL; TP53; deep-next generation sequencing; low-level mutational load; targeted-therapy.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

DNA Mutational Analysis
Female
High-Throughput Nucleotide Sequencing
Humans
Leukemia, Lymphocytic, Chronic, B-Cell* / genetics
Leukemia, Lymphocytic, Chronic, B-Cell* / metabolism
Leukemia, Lymphocytic, Chronic, B-Cell* / pathology
Male
Mutation*
Tumor Suppressor Protein p53 / genetics
Tumor Suppressor Protein p53 / metabolism

Substances

TP53 protein, human
Tumor Suppressor Protein p53