Big Strides in Cellular MicroRNA Expression

Trends Genet. 2018 Mar;34(3):165-167. doi: 10.1016/j.tig.2017.12.015. Epub 2018 Jan 18.

Abstract

A lack of knowledge of the cellular origin of miRNAs has greatly confounded functional and biomarkers studies. Recently, three studies characterized miRNA expression patterns across >78 human cell types. These combined data expand our knowledge of miRNA expression localization and confirm that many miRNAs show cell type-specific expression patterns.

Keywords: RNA-seq; cell expression; microRNA.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Eukaryotic Cells / cytology
  • Eukaryotic Cells / metabolism
  • Gene Expression Profiling / methods*
  • Gene Expression Regulation*
  • High-Throughput Nucleotide Sequencing / methods*
  • Humans
  • MicroRNAs / genetics*
  • Organ Specificity / genetics
  • RNA, Messenger / genetics

Substances

  • MicroRNAs
  • RNA, Messenger