Chinese Cervicocephalic artery dissection study (CCADS): rationale and protocol for a multicenter prospective cohort study

Zhu Zhu; Yuyuan Xu; Yilong Wang; Zhenhua Zhou; Xiang Han; Aihua Liu; Jing Peng; Yi Xu; Luyao Wang

doi:10.1186/s12883-018-1011-x

Chinese Cervicocephalic artery dissection study (CCADS): rationale and protocol for a multicenter prospective cohort study

BMC Neurol. 2018 Jan 11;18(1):6. doi: 10.1186/s12883-018-1011-x.

Authors

Zhu Zhu¹, Yuyuan Xu^{2

3

4

5}, Yilong Wang^{2

3

4

5}, Zhenhua Zhou⁶, Xiang Han⁷, Aihua Liu⁸, Jing Peng³, Yi Xu¹, Luyao Wang⁴

Affiliations

¹ Department of Neurology, State Key Laboratory of Medical Neurobiology, Huashan Hospital, Fudan University, Shanghai, China.
² Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
³ China National Clinical Research Center for Neurological Diseases, Beijing, China.
⁴ Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China.
⁵ Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China.
⁶ Department of Neurology, Southwest Hospital, Third Military Medical University, Chongqing, China.
⁷ Department of Neurology, State Key Laboratory of Medical Neurobiology, Huashan Hospital, Fudan University, Shanghai, China. hansletter@fudan.edu.cn.
⁸ Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, China; Beijing Neurosurgical Institute, Capital Medical University, Beijing, China.

Abstract

Background: Cervicocephalic artery dissection (CAD) is an important etiology of stroke in the youth. Findings from recent studies suggest it a "group of disease entities" with different underlying etiologies, presentations and prognosis, necessitating an integral study including various types of CAD to get a better understanding of this disease. In addition, Chinese patients with CAD are likely to carry different features from their western counterparts, which remains uncertain yet. Chinese Cervicocephalic Artery Dissection Study (CCADS) therefore aims at exploring the epidemiology, risk factors, clinical/radiological features, diagnosis and prognosis of CAD in Chinese patients.

Methods/design: CCADS is a multicenter prospective cohort study enrolling patients age ≥ 18 years with recent (<14 days after onset) CAD. Baseline clinical data, laboratory tests and imaging studies are performed within 3 days after admission, and follow-ups will be conducted through face-to-face interviews at discharge, 3 months, 6 months and 12 months after admission, when the modified Rankin Scale (mRS), cerebrovascular events, medication compliance, CAD evolution and so on are evaluated. Additional blood samples will also be collected at baseline, 3 and 12 months follow-up. The primary outcome is radiographic evolution of CAD; secondary outcomes include cerebrovascular events, major bleeding complications, all-cause mortality and functional independence.

Discussion: Through the integration of information on epidemiology, risk factors, clinical/radiological features and prognosis of various types of CAD in Chinese population, combined with the application of advanced imaging techniques, collection of potential blood biomarkers, and assessment of novel treatment strategies. CCADS will provide thorough information on CAD - the major cause of stroke in the youth, and play a role in prevention and treatment determination in the future.

Keywords: Biomarker; Cervicocephalic artery dissection; Cohort; Magnetic resonance imaging; Prognosis; Risk factors.

Publication types

Multicenter Study

MeSH terms

Adolescent
Aged
Aortic Dissection / complications*
Aortic Dissection / epidemiology*
Arteries / pathology
Asian People
Female
Humans
Male
Middle Aged
Prognosis
Prospective Studies
Research Design
Risk Factors
Stroke / epidemiology*
Stroke / etiology*