Microbiota and the liver

Liver Transpl. 2018 Apr;24(4):539-550. doi: 10.1002/lt.25008.

Abstract

The gut microbiome outnumbers the human genome by 150-fold and plays important roles in metabolism, immune system education, tolerance development, and prevention of pathogen colonization. Dysbiosis has been associated with nonalcoholic fatty liver disease (NAFLD), nonalcoholic steatohepatitis (NASH), and alcoholic liver disease (ALD) as well as cirrhosis and complications. This article provides an overview of this relationship. Liver Transplantation 24 539-550 2018 AASLD.

Publication types

  • Review

MeSH terms

  • Dysbiosis / immunology
  • Dysbiosis / metabolism*
  • Dysbiosis / microbiology
  • Gastrointestinal Microbiome / drug effects
  • Gastrointestinal Microbiome / immunology
  • Gastrointestinal Microbiome / physiology*
  • Graft Rejection / immunology
  • Graft Rejection / metabolism
  • Graft Rejection / prevention & control
  • Humans
  • Immunosuppressive Agents / adverse effects
  • Liver / immunology
  • Liver / metabolism*
  • Liver / pathology
  • Liver Diseases / immunology
  • Liver Diseases / metabolism*
  • Liver Diseases / microbiology
  • Liver Diseases / surgery
  • Liver Transplantation / adverse effects*
  • Perioperative Period
  • Probiotics / therapeutic use
  • Quality of Life

Substances

  • Immunosuppressive Agents