Transcriptional Regulation of Metabolism by SIRT1 and SIRT7

Kazuya Yamagata; Tatsuya Yoshizawa

doi:10.1016/bs.ircmb.2017.07.009

Transcriptional Regulation of Metabolism by SIRT1 and SIRT7

Int Rev Cell Mol Biol. 2018:335:143-166. doi: 10.1016/bs.ircmb.2017.07.009. Epub 2017 Aug 30.

Authors

Kazuya Yamagata¹, Tatsuya Yoshizawa²

Affiliations

¹ Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan. Electronic address: k-yamaga@kumamoto-u.ac.jp.
² Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.

PMID: 29305011
DOI: 10.1016/bs.ircmb.2017.07.009

Abstract

Sirtuins are a family of evolutionally conserved nicotinamide adenine dinucleotide (NAD⁺)-dependent protein deacetylases/deacylases that regulate metabolism. The mammalian sirtuin family consists of seven sirtuins (SIRT1-7). Recent findings have identified critical roles for SIRT1 and SIRT7 in glucose/lipid metabolism in multiple tissues. This review focuses on the metabolic roles of these two sirtuins and the benefits of modulating the activity of sirtuins for the treatment of metabolic diseases such as type 2 diabetes.

Keywords: SIRT1; SIRT7; Sirtuin.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Gene Expression Regulation*
Humans
Models, Biological
Organ Specificity
Sirtuins / metabolism*
Transcription, Genetic*

Substances

Sirtuins