Research on HIV cure: Mapping the ethics landscape

PLoS Med. 2017 Dec 8;14(12):e1002470. doi: 10.1371/journal.pmed.1002470. eCollection 2017 Dec.

Karine Dubé¹, Laurie Sylla², Lynda Dee^{3

4

5}, Jeff Taylor^{3

6}, David Evans^{4

7}, Carl Dean Bruton^{6

8}, Adam Gilberston⁹, Lisa Gralinski¹, Brandon Brown¹⁰, Asheley Skinner^{1

11}, Bryan J Weiner^{1

12}, Sandra B Greene¹, Amy Corneli¹¹, Adaora A Adimora¹³, Joseph D Tucker^{13

14}, Stuart Rennie^{9

15}

¹ University of North Carolina Gillings School of Global Public Health, Chapel Hill, North Carolina, United States of America.
² defeatHIV Community Advisory Board (CAB), Seattle, Washington, United States of America.
³ amfAR Institute for HIV Cure Research CAB, San Francisco, California, United States of America.
⁴ Delaney AIDS Research Enterprise (DARE) CAB, San Francisco, California, United States of America.
⁵ AIDS Action Baltimore, Baltimore, Maryland, United States of America.
⁶ Collaboratory of AIDS Researchers for Eradication (CARE) CAB, Palm Springs, California, and Chapel Hill, North Carolina, United States of America.
⁷ Project Inform, San Francisco, California, United States of America.
⁸ AIDS Clinical Trials Group (ACTG) CAB, Chapel Hill, North Carolina, United States of America.
⁹ Department of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America.
¹⁰ University of California Riverside, Riverside, California, United States of America.
¹¹ Duke Clinical Research Institute (DCRI), Durham, North Carolina, United States.
¹² Department of Global Health, University of Washington, Seattle, Washington, United States of America.
¹³ UNC Institute of Global Health and Infectious Diseases (IGHID), Chapel Hill, North Carolina, United States of America.
¹⁴ UNC Project China, Guangzhou, China.
¹⁵ UNC Center for Bioethics, Chapel Hill, North Carolina, United States of America.

Abstract

In an essay, Karine Dubé and coauthors discuss the ethics of preclinical and clinical studies relevant to achieving an HIV cure.