Identification and management of familial breast cancer in Austria

Horm Mol Biol Clin Investig. 2017 Nov 30;32(2):/j/hmbci.2017.32.issue-2/hmbci-2017-0025/hmbci-2017-0025.xml. doi: 10.1515/hmbci-2017-0025.

Abstract

Aim The aim of this study is to review the legal implications, the technology, the indications and the management of women with a familial background of breast and/or ovarian cancer. Methods We have reviewed the literature and national Austrian guidelines to describe the uptake of genetic counseling and the management options offered in Austria. Results Genetic testing for the BRCA1 and 2 mutations is free and readily available through a nation-wide program. Increased awareness and the availability of screening programs and prophylactic surgery have resulted in a profound increase in genetic counseling and testing in women with a familial background of breast and ovarian cancer in Austria. Conclusion While readily available country-wide counseling has led to an increase in counseling and testing, Austrian legislation mandates "non-directional counseling" resulting in a comparatively low uptake of prophylactic surgery.

Keywords: Austria; BRCA1; BRCA2; familial breast cancer; genetic counseling; national guidelines.

Publication types

  • Review

MeSH terms

  • Austria
  • BRCA1 Protein / genetics
  • BRCA2 Protein / genetics
  • Female
  • Genetic Counseling / methods*
  • Genetic Counseling / standards
  • Genetic Testing / methods*
  • Genetic Testing / standards
  • Hereditary Breast and Ovarian Cancer Syndrome / diagnosis*
  • Hereditary Breast and Ovarian Cancer Syndrome / epidemiology
  • Hereditary Breast and Ovarian Cancer Syndrome / genetics
  • Hereditary Breast and Ovarian Cancer Syndrome / therapy
  • Humans
  • Practice Guidelines as Topic

Substances

  • BRCA1 Protein
  • BRCA1 protein, human
  • BRCA2 Protein
  • BRCA2 protein, human