Objective: To investigate the risk factors of poor graft function (PGF) after allogeneic hematopoietic stem cell transplantation (allo-HSCT) for severe aplastic anemia (SAA) . Methods: Clinical data from 111 SAA patients who received allo-HSCT were analyzed retrospectively. Factors including age, gender, interval to transplantation, the level of serum ferritin before transplantation were analyzed by Cox multivariate regression analysis. Results: Among the 111 patients who underwent allo-HSCT, 16 developed PGF (14.4%) . Multivariate analysis showed donor type (HR=2.656, 95%CI 1.204-5.858, P= 0.016) and the level of serum ferritin before tansplantation (HR=3.170, 95%CI 1.400-7.180, P=0.006) were significant risk factors for PGF. Conclusion: Unrelated donor transplantation and the high level of serum ferritin before transplantation are risk factors for PGF.
目的： 探讨重型再生障碍性贫血（SAA）患者行异基因造血干细胞移植（allo-HSCT）后发生植入功能不良（PGF）的危险因素。 方法： 回顾性分析111例行allo-HSCT的SAA患者临床资料及移植情况，采用Cox比例风险模型对可能影响PGF的因素进行单因素及多因素分析。 结果： 在111例行allo-HSCT的SAA患者中，共有16例发生了PGF（14.4%）。多因素分析结果显示，非血缘供者（HR＝ 2.656，95%CI 1.204～5.858，P＝0.016）及移植前血清铁蛋白浓度（SF）>1 000 μg/L（HR＝3.170，95%CI 1.400～7.180，P＝0.006）是发生PGF的独立危险因素。 结论： 非血缘供者及移植前SF>1 000 μg/L的患者移植后容易发生PGF。.
Keywords: Anemia, aplastic; Hematopoietic stem cell transplantation; Poor graft function; Risk factors.