Purpose: Checkpoint inhibitors are now a common treatment modality for metastatic cancer. In this manuscript, we describe the clinical features and management of autoimmune non-infectious uveitis induced by this class of drugs.
Methods: Seven patients undergoing checkpoint inhibitor treatment for metastatic cancer from uveitis practices at three tertiary referral centers.
Results: All seven patients developed various severities of ocular inflammatory disease while taking checkpoint inhibitors for metastatic disease.
Conclusions: Checkpoint inhibitors may induce autoimmune uveitis. Ocular complaints should prompt an early evaluation by an ophthalmologist.
Keywords: Autoimmune uveitis; Checkpoint inhibitors; Metastatic cancer.