We report a case of ovarian function fluctuation during long-term follow-up in a patient with premature ovarian insufficiency (POI). The patient finally obtained clinical pregnancy with subsequent uneventful full-term delivery after several intracytoplasmic sperm injection-embryo transfer (ICSI-ET) cycles. This case demonstrates that hormone replacement therapy (HRT) and assisted reproductive therapy should be applied as soon as possible to young patients with POI who have a strong desire for pregnancy in the absence of contraindications. This strategy helps such patients obtain pregnancy and delivery before the exhaustion of ovarian function.
报道1例早发性卵巢功能不全患者在长期密切监测过程中出现卵巢功能的波动，并行多次卵胞浆内单精子显微注射-胚胎移植治疗，最终获得临床妊娠和分娩的病例并进行相关文献复习。提示对于较年轻、有强烈生育愿望的早发性卵巢功能不全患者，应该在排除禁忌症后尽早开始激素替代治疗，积极进行辅助生殖助孕，仍有望在卵巢功能完全耗竭之前获得正常妊娠分娩。