The Role of Phylogenetics as a Tool to Predict the Spread of Resistance

Anna Zhukova; Teresa Cutino-Moguel; Olivier Gascuel; Deenan Pillay

doi:10.1093/infdis/jix411

The Role of Phylogenetics as a Tool to Predict the Spread of Resistance

J Infect Dis. 2017 Dec 1;216(suppl_9):S820-S823. doi: 10.1093/infdis/jix411.

Authors

Anna Zhukova¹, Teresa Cutino-Moguel², Olivier Gascuel¹, Deenan Pillay^{3

4}

Affiliations

¹ Unité Bioinformatique Evolutive, Centre de Bioinformatique, Biostatistique et Biologie Intégrative, C3BI USR 3756 Institut Pasteur et CNRS, France.
² Virology Department, UCLH NHS Foundation Trust, London.
³ Division of Infection and Immunity, University College London, United Kingdom.
⁴ Africa Health Research Institute, KwaZulu-Natal, South Africa.

Abstract

Drug resistance mutations emerge in genetic sequences of HIV through drug-selective pressure. Drug resistance can be transmitted. In this review we discuss phylogenetic methods used to study the emergence of drug resistance and the spread of resistant viruses.

Keywords: HIV; drug resistance; phylogenetics.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Anti-HIV Agents / therapeutic use*
Drug Resistance, Viral / genetics
HIV / drug effects
HIV / genetics*
HIV Infections / drug therapy
HIV Infections / epidemiology*
HIV Infections / virology
Humans
Mutation / genetics
Phylogeny

Substances

Anti-HIV Agents