Quantifying Guest Exchange in Supramolecular Systems

Liat Avram; Anthony D Wishard; Bruce C Gibb; Amnon Bar-Shir

doi:10.1002/anie.201708726

Quantifying Guest Exchange in Supramolecular Systems

Angew Chem Int Ed Engl. 2017 Nov 27;56(48):15314-15318. doi: 10.1002/anie.201708726. Epub 2017 Oct 20.

Authors

Liat Avram¹, Anthony D Wishard², Bruce C Gibb², Amnon Bar-Shir³

Affiliations

¹ Department of Chemical Research Support, The Weizmann Institute of Science, 7610001, Rehovot, Israel.
² Department of Chemistry, Tulane University, New Orleans, LA, 70118, USA.
³ Department of Organic Chemistry, The Weizmann Institute of Science, 7610001, Rehovot, Israel.

PMID: 28972281
DOI: 10.1002/anie.201708726

Abstract

The ability to accurately determine and quantitatively evaluate kinetic phenomena associated with supramolecular assemblies, in real time, is key to a better understanding of their defined architectures and diverse functionalities. Therefore, analytical tools that can precisely assess a wide range of exchange rates within such systems are of considerable importance. This study demonstrates the ability to use an NMR approach based on saturation transfer for the determination of rates of guest exchange from molecular capsules. By using cavitands that assemble into distinct dimeric assemblies, we show that this approach, which we term guest exchange saturation transfer (GEST), allows the use of a conventional NMR setup to study and quantitatively assess a wide range of exchange rates, from 35 to more than 5000 s^-1 .

Keywords: GEST; NMR spectroscopy; exchange rates; host-guest systems; supramolecular chemistry.

Publication types

Research Support, Non-U.S. Gov't