Rationale for Adjunctive Therapies for Pediatric Sepsis Induced Multiple Organ Failure

Abstract

Adjunctive therapies have been proposed for use in at least 5 inflammation pathobiology phenotypes in pediatric sepsis-induced multiple organ failure. This article discusses host-pathogen interaction prototypes to facilitate understanding of the rationale for personalized therapy in these phenotypes. The article discusses the literature on adjunctive antiinflammatory and immune modulation therapies that, in addition to traditional organ support and infection source control, might be part of a personalized precision medicine approach to the reversal of each of these inflammatory pathobiology phenotypes.

Keywords: Hyperleukocytosis; Immune paralysis; Macrophage activation syndrome; Sequential MOF; Thrombocytopenia-associated MOF.