International cancer seminars: a focus on esophageal squamous cell carcinoma

G Murphy; V McCormack; B Abedi-Ardekani; M Arnold; M C Camargo; N A Dar; S M Dawsey; A Etemadi; R C Fitzgerald; D E Fleischer; N D Freedman; A M Goldstein; S Gopal; M Hashemian; N Hu; P L Hyland; B Kaimila; F Kamangar; R Malekzadeh; C G Mathew; D Menya; G Mulima; M M Mwachiro; A Mwasamwaja; N Pritchett; Y-L Qiao; L F Ribeiro-Pinto; M Ricciardone; J Schüz; F Sitas; P R Taylor; K Van Loon; S-M Wang; W-Q Wei; C P Wild; C Wu; C C Abnet; S J Chanock; P Brennan

doi:10.1093/annonc/mdx279

International cancer seminars: a focus on esophageal squamous cell carcinoma

Ann Oncol. 2017 Sep 1;28(9):2086-2093. doi: 10.1093/annonc/mdx279.

Authors

G Murphy¹, V McCormack², B Abedi-Ardekani³, M Arnold⁴, M C Camargo¹, N A Dar⁵, S M Dawsey¹, A Etemadi¹, R C Fitzgerald⁶, D E Fleischer⁷, N D Freedman¹, A M Goldstein¹, S Gopal⁸, M Hashemian^{1

9}, N Hu¹, P L Hyland¹, B Kaimila⁸, F Kamangar¹⁰, R Malekzadeh⁹, C G Mathew^{11

12}, D Menya¹³, G Mulima⁸, M M Mwachiro¹⁴, A Mwasamwaja¹⁵, N Pritchett¹, Y-L Qiao¹⁶, L F Ribeiro-Pinto¹⁷, M Ricciardone¹⁸, J Schüz², F Sitas^{19

20}, P R Taylor¹, K Van Loon²¹, S-M Wang^{1

16}, W-Q Wei¹⁶, C P Wild²², C Wu¹⁶, C C Abnet¹, S J Chanock¹, P Brennan³

Affiliations

¹ Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda Maryland, USA.
² Section of Environment and Radiation.
³ Section of Genetics.
⁴ Cancer Surveillance, International Agency for Research on Cancer, Lyon, France.
⁵ Department of Biochemistry, University of Kashmir, Hazratbal, Srinagar, Jammu and Kashmir, India.
⁶ MRC Cancer Unit, Hutchison-MRC Research Centre, University of Cambridge, Cambridge, UK.
⁷ Department of Internal Medicine, Mayo Clinic, Scottsdale, Arizona, USA.
⁸ University of North Carolina Project-Malawi, Lilongwe, Malawi.
⁹ Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
¹⁰ Department of Public Health Analysis, School of Community Health and Policy, Morgan State University, Baltimore, Maryland, USA.
¹¹ Department of Medical and Molecular Genetics, Kings College London.
¹² Sydney Brenner Institute for Molecular Bioscience, University of Witwatersrand, Johannesburg, South Africa.
¹³ School of Public Health, Moi University, Eldoret, Kenya.
¹⁴ Tenwek Hospital, Bomet, Kenya.
¹⁵ Kilimanjaro Christian Medical Centre, Moshi, Tanzania.
¹⁶ Department of Etiology and Carcinogenesis & Department of Cancer Epidemiology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
¹⁷ Molecular Carcinogenesis Program, Institute Nacional de Cancer, Sao Paulo, Brazil.
¹⁸ National Cancer Institute, Center for Global Health, National Institutes of Health, Bethesda, Maryland, USA.
¹⁹ School of Public Health, University of Sydney, New South Wales, Australia.
²⁰ School of Public Health & Community Medicine, University of New South Wales, Sydney, Australia.
²¹ Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, California, USA.
²² International Agency for Research on Cancer, Lyon, France.

Abstract

The International Agency for Research on Cancer (IARC) and the US National Cancer Institute (NCI) have initiated a series of cancer-focused seminars [Scelo G, Hofmann JN, Banks RE et al. International cancer seminars: a focus on kidney cancer. Ann Oncol 2016; 27(8): 1382-1385]. In this, the second seminar, IARC and NCI convened a workshop in order to examine the state of the current science on esophageal squamous cell carcinoma etiology, genetics, early detection, treatment, and palliation, was reviewed to identify the most critical open research questions. The results of these discussions were summarized by formulating a series of 'difficult questions', which should inform and prioritize future research efforts.

Keywords: clinical research; early detection; epidemiology; esophageal squamous cell carcinoma (ESCC); genomics.

Published by Oxford University Press on behalf of the European Society for Medical Oncology 2017. This work is written by US Government employees and is in the public domain in the US.

Publication types

Review

MeSH terms

Carcinoma, Squamous Cell* / epidemiology
Carcinoma, Squamous Cell* / genetics
Carcinoma, Squamous Cell* / therapy
Early Detection of Cancer
Esophageal Neoplasms* / epidemiology
Esophageal Neoplasms* / genetics
Esophageal Neoplasms* / therapy
Esophageal Squamous Cell Carcinoma
Humans
Internationality*
Risk Factors

Abstract

Publication types

MeSH terms

Grants and funding