Atopic dermatitis: pathogenesis

Emma Guttman-Yassky; Andrea Waldman; Jusleen Ahluwalia; Peck Y Ong; Lawrence F Eichenfield

doi:10.12788/j.sder.2017.036

Atopic dermatitis: pathogenesis

Semin Cutan Med Surg. 2017 Sep;36(3):100-103. doi: 10.12788/j.sder.2017.036.

Authors

Emma Guttman-Yassky¹, Andrea Waldman^{2

3}, Jusleen Ahluwalia^{2

3}, Peck Y Ong^{4

5}, Lawrence F Eichenfield^{2

3}

Affiliations

¹ Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York, New York, USA. eguttman@mail.rockefeller.edu.
² Division of Pediatric and Adolescent Dermatology, Rady Children's Hospital, San Diego, California, USA.
³ Departments of Dermatology and Pediatrics, University of California, San Diego School of Medicine, San Diego, California, USA.
⁴ Department of Pediatrics, University of Southern California, Keck School of Medicine, Los Angeles, California, USA.
⁵ Division of Clinical Immunology and Allergy, Children's Hospital of Los Angeles, California, USA.

PMID: 28895955
DOI: 10.12788/j.sder.2017.036

Abstract

Atopic Dermatitis (AD) is a complex inflammatory cutaneous disorder characterized by immune mediated inflammation and epidermal barrier dysfunction. Arising from a complex interplay between environmental and genetic factors, the definitive etiology of AD is perplexing and controversial. Advances in molecular medicine are radically transforming our understanding of AD pathogenesis. Increasing knowledge on the pathogenesis of AD results in novel therapeutic targets and pathways. This article details the pathogenesis section of the Curriculum United for Better Eczema Care (CUBE-C), facilitating primary care and sub-specialist education on the scientific advances driving recent AD therapeutic innovations.

Publication types

Review

MeSH terms

Dermatitis, Atopic / etiology*
Dermatitis, Atopic / genetics
Dermatitis, Atopic / immunology
Dermatitis, Atopic / physiopathology
Environment
Epidermis / physiopathology
Humans
Microbiota
Skin / microbiology