Association of Trial Registration With Reporting of Primary Outcomes in Protocols and Publications

An-Wen Chan; Annukka Pello; Jessica Kitchen; Anna Axentiev; Jorma I Virtanen; Annie Liu; Elina Hemminki

doi:10.1001/jama.2017.13001

Association of Trial Registration With Reporting of Primary Outcomes in Protocols and Publications

JAMA. 2017 Nov 7;318(17):1709-1711. doi: 10.1001/jama.2017.13001.

Authors

An-Wen Chan¹, Annukka Pello², Jessica Kitchen¹, Anna Axentiev¹, Jorma I Virtanen³, Annie Liu¹, Elina Hemminki⁴

Affiliations

¹ Women's College Research Institute, University of Toronto, Toronto, Ontario, Canada.
² University of Helsinki, Helsinki, Finland.
³ University of Oulu, Oulu, Finland.
⁴ National Institute for Health and Welfare, Helsinki, Finland.

Abstract

This study characterizes discrepancies between primary outcomes specified in trial protocols, registrations, and publications, and the association between prospective registration and consistency of published outcomes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Clinical Protocols
Clinical Trials as Topic*
Cohort Studies
Finland
Humans
Logistic Models
Registries*
Research Design

Grants and funding

CIHR/Canada