Doehl et al. have combined empirical data with computer simulation to demonstrate that RAG-2 mice intravenously infected with Leishmania donovani form heterogeneous skin parasite patches that govern infectiousness to sand flies. This model provides a much-needed tool to explore the relevance of asymptomatic and symptomatic visceral leishmaniasis patients as infection reservoirs.
Keywords: Leishmania donovani; anthroponotic visceral leishmaniasis; bite site; outward transmission; skin parasite patches; vector sand flies.
Published by Elsevier Ltd.