Cancer Evolution Constrained by the Immune Microenvironment

Nicholas McGranahan; Charles Swanton

doi:10.1016/j.cell.2017.08.012

Cancer Evolution Constrained by the Immune Microenvironment

Cell. 2017 Aug 24;170(5):825-827. doi: 10.1016/j.cell.2017.08.012.

Authors

Nicholas McGranahan¹, Charles Swanton²

Affiliations

¹ Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK.
² Cancer Research UK Lung Cancer Centre of Excellence, University College London Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, UK; Translational Cancer Therapeutics Laboratory, The Francis Crick Institute, 1 Midland Rd, London, NW1 1AT, UK. Electronic address: charles.swanton@crick.ac.uk.

PMID: 28841415
DOI: 10.1016/j.cell.2017.08.012

Abstract

Tumor development is a Darwinian evolutionary process, involving the interplay between cancer subclones and the local immune microenvironment. These complex interactions are highlighted in this issue of Cell by the results from Jiménez-Sánchez et al. of a deep analysis of one patient with advanced serous carcinoma of the ovary.

Cancer Evolution Constrained by the Immune Microenvironment

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Abstract

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