Members of FOX family could be drug targets of cancers

Jinhua Wang; Wan Li; Ying Zhao; De Kang; Weiqi Fu; Xiangjin Zheng; Xiaocong Pang; Guanhua Du

doi:10.1016/j.pharmthera.2017.08.003

Members of FOX family could be drug targets of cancers

Pharmacol Ther. 2018 Jan:181:183-196. doi: 10.1016/j.pharmthera.2017.08.003. Epub 2017 Aug 19.

Authors

Jinhua Wang¹, Wan Li², Ying Zhao², De Kang², Weiqi Fu², Xiangjin Zheng², Xiaocong Pang², Guanhua Du³

Affiliations

¹ The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, 100050 Beijing, China; Key Laboratory of Drug Target Research and Drug Screen, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, 100050 Beijing, China.
² Key Laboratory of Drug Target Research and Drug Screen, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, 100050 Beijing, China.
³ The State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, 100050 Beijing, China; Key Laboratory of Drug Target Research and Drug Screen, Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, 100050 Beijing, China. Electronic address: dugh@imm.ac.cn.

PMID: 28830838
DOI: 10.1016/j.pharmthera.2017.08.003

Abstract

FOX families play important roles in biological processes, including metabolism, development, differentiation, proliferation, apoptosis, migration, invasion and longevity. Here we are focusing on roles of FOX members in cancers, FOX members and drug resistance, FOX members and stem cells. Finally, FOX members as drug targets of cancer treatment were discussed. Future perspectives of FOXC1 research were described in the end.

Keywords: Cancer; Drug resistance; Drug target; FOX family; FOXM1; Stem cell.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Drug Resistance / physiology*
Forkhead Transcription Factors / drug effects
Forkhead Transcription Factors / physiology*
Humans
Molecular Targeted Therapy / methods*
Neoplasms / drug therapy*
Neoplasms / physiopathology*
Stem Cells / physiology*

Substances

Forkhead Transcription Factors