We Can Still Be Friends: IFN-γ Breaks Up Macrophage Enhancers

Boris Novakovic; Cheng Wang; Colin Logie

doi:10.1016/j.immuni.2017.08.002

We Can Still Be Friends: IFN-γ Breaks Up Macrophage Enhancers

Immunity. 2017 Aug 15;47(2):209-211. doi: 10.1016/j.immuni.2017.08.002.

Authors

Boris Novakovic¹, Cheng Wang¹, Colin Logie²

Affiliations

¹ Department of Molecular Biology, Radboud Institute of Molecular Life Sciences and Faculty of Science, Radboud University, 6525 GA Nijmegen, the Netherlands.
² Department of Molecular Biology, Radboud Institute of Molecular Life Sciences and Faculty of Science, Radboud University, 6525 GA Nijmegen, the Netherlands. Electronic address: c.logie@science.ru.nl.

PMID: 28813650
DOI: 10.1016/j.immuni.2017.08.002

Abstract

Interferon (IFN)-γ can prime macrophages for inflammatory responses by several mechanisms, including enhancer establishment and gene activation. In this issue of Immunity, Kang et al. (2017) provide insight into the mechanisms of IFN-γ-mediated gene repression as they show that IFN-γ promotes the disassembly of select active enhancers by interfering with enhancer-binding transcription factor MAF.

Publication types

Comment

MeSH terms

Friends
Humans
Interferon-gamma / immunology*
Macrophage Activation / immunology
Macrophages / immunology*
Regulatory Sequences, Nucleic Acid
Transcriptional Activation

Substances

Interferon-gamma