Uncovering the immunotherapeutic cycle initiated by p19Arf and interferon-β gene transfer to cancer cells: An inducer of immunogenic cell death

Ruan F V Medrano; Aline Hunger; João P P Catani; Bryan E Strauss

doi:10.1080/2162402X.2017.1329072

Uncovering the immunotherapeutic cycle initiated by p19Arf and interferon-β gene transfer to cancer cells: An inducer of immunogenic cell death

Oncoimmunology. 2017 May 19;6(7):e1329072. doi: 10.1080/2162402X.2017.1329072. eCollection 2017.

Authors

Ruan F V Medrano¹, Aline Hunger¹, João P P Catani¹, Bryan E Strauss¹

Affiliation

¹ Viral Vector Laboratory, Center for Translational Investigation in Oncology, Cancer Institute of Sao Paulo/LIM 24, University of Sao Paulo School of Medicine, Sao Paulo, Brazil.

Abstract

Simultaneous reestablishment of p53/p19^Arf and interferon-β pathways in melanoma cells culminates in a cell death process that displays features of necroptosis along with the release of immunogenic cell death molecules and unleashes an antitumor immune response mediated by natural killer cells, neutrophils as well as CD4⁺ and CD8⁺ T lymphocytes.

Keywords: Adenovirus; gene therapy; immunogenic cell death; immunotherapy; melanoma; p53.

Publication types

Review
Research Support, Non-U.S. Gov't