Objective: To analyze the patterns of female breast cancer and their incidence in Shanghai during 2003-2012, and to compare them with international data. Methods: The data of female breast cancer cases diagnosed between 2003 and 2012 were collected from the Shanghai Cancer Registry. The record of cancer cases included the patient's name, gender, date of birth, permanent and residential address, diagnosis site or name, histological type, date of first diagnosis, diagnostic basis and diagnostic stage, etc. Data source of cancer incidence of World, Developed Countries, Developing Countries, East Asia and China in 2012 sourced from GLOBOCAN 2012 database of the WHO International Agency for Research on Cancer (IARC); and the data of USA during 2008-2012 was collected from SEER 18 database from Surveillance, Epidemiology, and End Results Program of the National Cancer Institute (NCI). Incidence indicators of Shanghai female breast cancer were calculated, including the average cases, median age, average age, proportion, crude rate, age-specific rate and age-standardized rate. Results: During 2003-2012, 41 991 new cases of female breast cancer were diagnosed in Shanghai, with an average of 4 199 cases per year, accounting for 17.23% among total new female cancer cases, ranking first in female cancer incidence in Shanghai during 2003-2012, with a crude incidence rate of 60.90 per 100 000 and an age-standardized incidence rate of 33.90 per 100 000. During 2008-2012, an average 4 528 new cases of female breast cancer was diagnosed per year in Shanghai, with 16.97% among total female cancer cases. The median age was 56 years old and the mean age was 57.73 years old. The crude rate was 64.23 per 100 000 and the age-standardized rate was 35.00 per 100 0000, which was higher than those of China (22.1 per 100 000), Eastern Areas (27.0 per 100 000) and Developing Counties (31.3 per 100 000), and lower than that of World (43.1 per 100 000), and Yellow Race Population of USA (68.77 per 100 000). During 2003-2007, on average, 3 869 new cases of female breast cancer were diagnosed per year in Shanghai, accounting for 17.54% of total female cancer cases. The median age was 53 years old and the mean age was 56.44 years old. The crude rate was 57.42 per 100 000 and the age-standardized rate was 32.69 per 100 000. There was a continuing peak stage spanned 25 years old from 50 to 74 years old, during 2008-2012. Compared with those of 2003-2007, the beginning age group of the continuing peak stage was delayed for 5 years old and the ending age group was delayed for 10 years old. Conclusion: The age-standardized incidence rate in Shanghai was higher than those of China, Eastern Areas and Developing Counties, and lower than that of World, and that of Yellow Race Population of USA; Compared with 2003-2007, the crude rate and age-standardized rate increased, the median age, mean age and the beginning and ending age group of the continuing peak stage were delayed.
目的： 分析2003—2012年上海市女性乳腺癌病例发病特征，并与国际数据进行比较。 方法： 病例资料来自上海市恶性肿瘤病例报告登记系统中记录的2003—2012年诊断的所有女性乳腺癌病例。恶性肿瘤病例登记信息包括：患者姓名、性别、出生日期、户籍及居住地址、诊断部位或名称、病理学类型、首次诊断日期、诊断依据、诊断时期别等。2012年世界、发达国家、发展中国家、东亚地区和中国的恶性肿瘤发病数据来自WHO国际癌症研究机构（IARC）的GLOBOCAN 2012数据库；2008—2012年美国恶性肿瘤发病数据来自美国国立癌症研究所（NCI）的SEER 18数据库。计算上海市女性乳腺癌年均发病例数、平均年龄、构成比、发病率、年龄别发病率、标化发病率。 结果： 2003—2012年，上海市新诊断女性乳腺癌病例41 991例，年均4 199例，占全部女性恶性肿瘤的17.23%，发病率为60.90/10万，标化发病率为33.90/10万。2008—2012年，年均发病4 528例，占全部女性恶性肿瘤的16.97%，发病中位年龄为56岁，平均年龄为57.73岁，发病率为64.23/10万，标化发病率为35.00/10万（高于2012年中国、东亚地区和发展中国家的22.1/10万、27.0/10万和31.3/10万，低于世界水平的43.1/10万；低于2008—2012年美国黄种人的68.77/10万）；2003—2007年，年均发病3 869例，占全部女性恶性肿瘤的17.54%，发病中位年龄为53岁，平均年龄为56.44岁，发病率为57.42/10万，标化发病率为32.69/10万。2008—2012年，年龄别发病率曲线存在一个从50~74岁跨度长达25岁的高峰平台，相比2003—2007年的高峰平台起始年龄推迟5岁，终止年龄推迟10岁。 结论： 2008—2012年，上海女性乳腺癌标化发病率高于2012年中国、东亚地区和发展中国家，低于世界水平；低于2008—2012年美国黄种人；相比2003—2007年，发病率和标化发病率增高，发病中位年龄、平均年龄和年龄别发病率高峰平台起止年龄推迟。.
Keywords: Breast Cancer; Epidemiology; Incidence.