Objective: To evaluate the influence of oral hygiene on risk of oral cancer in non-smoking and non-drinking women. Methods: From September 2010 to February 2016, 242 non-smoking and non-drinking female patients with pathologically confirmed oral cancer were recruited in a hospital of Fuzhou, and another 856 non-smoking and non-drinking healthy women from health examination center in the same hospital were selected as control group. Five oral hygiene related variables including the frequency of teeth brushing, number of teeth lost, poor prosthesis, regular dental visits and recurrent dental ulceration were used to develop oral hygiene index model. Unconditional logistic regression was used to calculate odds ratios (OR) and 95% confidence intervals (95%CI). The area under the receiver operating characteristic curve (AUROC) was used to evaluate the predictability of the oral hygiene index model. Multivariate logistic regression model was used to analyze the association between oral hygiene index and the incidence of oral cancer. Results: Teeth brushing <2 twice daily, teeth lost ≥5, poor prosthesis, no regular dental visits, recurrent dental ulceration were risk factors for the incidence of oral cancer in non-smoking and non-drinking women, the corresponding OR (95%CI) were 1.50 (1.08-2.09), 1.81 (1.15-2.85), 1.51 (1.03-2.23), 1.73 (1.15-2.59), 7.30 (4.00-13.30), respectively. The AUROC of the oral hygiene index model was 0.705 9, indicating a high predictability. Multivariate logistic regression showed that the oral hygiene index was associated with risk of oral cancer. The higher the score, the higher risk was observed. The corresponding OR (95%CI) of oral hygiene index scores (score 1, score 2, score 3, score 4-5) were 2.51 (0.84-7.53), 4.68 (1.59-13.71), 6.47 (2.18-19.25), 15.29 (5.08-45.99), respectively. Conclusion: Oral hygiene could influence the incidence of oral cancer in non-smoking and non-drinking women, and oral hygiene index has a certain significance in assessing the combined effects of oral hygiene.
目的： 探讨口腔卫生状况对非吸烟非饮酒女性口腔癌发病的影响。 方法： 收集2010年9月至2016年2月福州某医院经术后病理确诊的非吸烟非饮酒女性口腔癌患者242例，同期选取该医院体检非吸烟非饮酒健康女性作为对照组（856名）。纳入刷牙频率、牙齿缺失数、口腔不良修复体、规律性看牙医、复发性口腔溃疡等5项口腔卫生指标，构建口腔卫生指数模型，应用非条件logistic回归模型计算OR（95%CI）值，并根据受试者工作特征曲线下面积（AUROC）评价模型的预测效能。应用多因素logistic回归模型分析口腔卫生指数与口腔癌发病的关联。 结果： 刷牙频率<2次/d、牙齿缺失≥5颗、有口腔不良修复体、无规律性看牙医、有复发性口腔溃疡是非吸烟非饮酒女性口腔癌发病的危险因素，OR(95%CI)值分别为1.50(1.08~2.09)、1.81(1.15~2.85)、1.51(1.03~2.23)、1.73(1.15~2.59)、7.30(4.00~13.30)。构建的口腔卫生指数模型的AUROC为0.705 9，检验效能较好。多因素logistic回归模型分析结果显示，口腔卫生指数与口腔癌存在关联，分值越高，危险程度就越大；口腔卫生指数得分为1、2、3、4~5分的OR(95%CI)值分别为2.51(0.84~7.53)、4.68(1.59~13.71)、6.47(2.18~19.25)、15.29(5.08~45.99)。 结论： 口腔卫生对非吸烟非饮酒女性口腔癌发病有一定影响，口腔卫生指数对评估口腔卫生的综合作用具有一定意义。.
Keywords: Case-control studies; Females; Mouth neoplasms; Oral hygiene.