Abstract
In addition to morphine-selective mu 2 and enkephalin-preferring delta sites, recent evidence supports the presence within the central nervous system of a common site with very high affinity for both enkephalins and opiates termed the mu 1 site. This concept of a common, very high affinity site for multiple neurotransmitters is a unique concept in neuropharmacology, differing from classical transmitter systems which possess multiple receptor classes for a single transmitter. This review will address both the biochemical and pharmacological evidence supporting the existence of this site.
MeSH terms
-
Aging
-
Analgesia
-
Animals
-
Autoradiography
-
Binding, Competitive
-
Brain / metabolism
-
Dihydromorphine / metabolism
-
Endorphins / physiology
-
Enkephalin, Leucine / analogs & derivatives
-
Enkephalin, Leucine / metabolism
-
Enkephalin, Leucine-2-Alanine
-
Enkephalins / metabolism
-
Ethylmaleimide / pharmacology
-
Morphine / metabolism
-
Naloxone / analogs & derivatives
-
Naloxone / metabolism
-
Naloxone / pharmacology
-
Neurotransmitter Agents / physiology
-
Phylogeny
-
Receptors, Opioid / drug effects
-
Receptors, Opioid / physiology*
-
Receptors, Opioid, mu
-
Respiration
-
Substance-Related Disorders / physiopathology
-
Tissue Distribution
Substances
-
Endorphins
-
Enkephalins
-
Neurotransmitter Agents
-
Receptors, Opioid
-
Receptors, Opioid, mu
-
Naloxone
-
Enkephalin, Leucine
-
Enkephalin, Leucine-2-Alanine
-
naloxazone
-
Morphine
-
naloxonazine
-
Dihydromorphine
-
Ethylmaleimide