Exploring substrate specificities of a recombinant Rhizopus oryzae lipase in biodiesel synthesis

N Biotechnol. 2017 Oct 25;39(Pt A):59-67. doi: 10.1016/j.nbt.2017.07.003. Epub 2017 Jul 12.

Abstract

The alcoholysis of triolein was used to explore the specific features of a recombinant Rhizopus oryzae lipase (rROL) for biodiesel synthesis. For this purpose, different acylglycerols were compared as substrates in lipase-catalysed transesterification. rROL was shown to exhibit a higher specificity towards 1-monoolein than triolein compared to other R. oryzae lipases, being more than 4-fold more specific; in contrast, rROL did not accept 2-monoolein as substrate, concluding that it is highly 1,3-positional specific. Comparing ethanol and methanol as acyl-acceptors, it was observed that the latter caused more lipase inactivation. Regarding alcohols, it was also demonstrated that acyl migration occurred in moderate alcohol concentrations.

Keywords: Acylglycerols; Biodiesel; Lipase; Rhizopus oryzae; Transesterification.

MeSH terms

  • Biocatalysis
  • Biofuels*
  • Esterification
  • Lipase / metabolism*
  • Organic Chemicals / chemistry
  • Recombinant Proteins / metabolism*
  • Rhizopus / enzymology*
  • Substrate Specificity
  • Time Factors
  • Triolein / metabolism
  • Water / chemistry

Substances

  • Biofuels
  • Organic Chemicals
  • Recombinant Proteins
  • Water
  • Triolein
  • Lipase