Abstract
Seven new dianthrone glycosides, named polygonumnolides A1-B3 (1-7), were isolated from the 70 % EtOH extract of the dried roots of Polygonum multiflorum Thunb. using column chromatography and preparative high-performance liquid chromatography. Their structures were determined by 1D and 2D NMR and mass spectroscopy. The isolated compounds were evaluated for their cytotoxic effects against KB tumor cell lines and compounds 1-4 showed moderate cytotoxicity.
Keywords:
Dianthrone glycosides; KB tumor cell lines; Polygonum multiflorum Thunb.; Polygonumnolides A1–B3.
MeSH terms
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology*
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Cell Line, Tumor
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Chromatography, High Pressure Liquid
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Drug Screening Assays, Antitumor
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Fallopia multiflora / chemistry*
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Glycosides / chemistry
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Glycosides / isolation & purification
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Glycosides / pharmacology*
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Humans
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Inhibitory Concentration 50
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Magnetic Resonance Spectroscopy
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Plant Extracts / chemistry*
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Plant Roots / chemistry
Substances
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Antineoplastic Agents, Phytogenic
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Glycosides
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Plant Extracts