Association of CD58 gene polymorphisms with NMO spectrum disorders in a Han Chinese population

J Neuroimmunol. 2017 Aug 15:309:23-30. doi: 10.1016/j.jneuroim.2017.05.003. Epub 2017 May 11.

Abstract

This study aimed to perform a comprehensive assessment of the association between CD58 polymorphisms and the risk of neuromyelitis optica spectrum disorders (NMOSD) in a Han Chinese population. Nine single-nucleotide polymorphisms (SNPs) were genotyped in 230 NMOSD patients and 487 healthy controls. Five SNPs were significantly associated with an increased risk of NMOSD (rs2300747, rs1335532, rs56302466, rs1016140, and rs12044852). The haplotype TAGCCCAA significantly increased the risk of NMOSD, while TATTACGG reduced the risk. In conclusion, this study identified a new NMOSD susceptibility variant, rs56302466, and suggested that CD58 polymorphisms are associated with the risk of NMOSD in Han Chinese.

Keywords: Autoimmune diseases; CD58; Genetics; Haplotype; Neuromyelitis optica spectrum disorders; Single-nucleotide polymorphism.

MeSH terms

  • Adult
  • Asian People / genetics*
  • CD58 Antigens / genetics*
  • Female
  • Genetic Association Studies / methods*
  • Genetic Variation / genetics
  • Humans
  • Male
  • Middle Aged
  • Neuromyelitis Optica / diagnosis
  • Neuromyelitis Optica / epidemiology*
  • Neuromyelitis Optica / genetics*
  • Polymorphism, Single Nucleotide / genetics*

Substances

  • CD58 Antigens