Reaction of azides and enolisable aldehydes under the catalysis of organic bases and Cinchona based quaternary ammonium salts

Org Biomol Chem. 2017 Jun 21;15(24):5227-5235. doi: 10.1039/c7ob00799j.

Abstract

Herein we report a two-step sequence for the preparation of amides starting from azides and enolisable aldehydes. The reaction proceeded via the formation of triazoline intermediates that were converted into amides via Lewis acid catalysis. Preliminary studies on the preparation of triazolines under chiral phase transfer catalysis are also presented, demonstrating that enantioenriched amides could be prepared from achiral aldehydes in moderate to low enantioselectivity.

MeSH terms

  • Aldehydes / chemistry*
  • Amides / chemical synthesis*
  • Amides / chemistry
  • Azides / chemistry*
  • Catalysis
  • Cinchona / chemistry*
  • Molecular Structure
  • Quaternary Ammonium Compounds / chemistry*
  • Salts / chemistry

Substances

  • Aldehydes
  • Amides
  • Azides
  • Quaternary Ammonium Compounds
  • Salts