Update on Radiotherapy for Central Nervous System Malignancies

Eric Kemmerer; Sunjay Shah

doi:10.1016/j.soc.2017.01.003

Update on Radiotherapy for Central Nervous System Malignancies

Surg Oncol Clin N Am. 2017 Jul;26(3):347-355. doi: 10.1016/j.soc.2017.01.003. Epub 2017 May 11.

Authors

Eric Kemmerer¹, Sunjay Shah²

Affiliations

¹ Department of Radiation Oncology, Drexel University College of Medicine, 245 North 15 Street, Philadelphia, PA 19102, USA. Electronic address: Eric.Kemmerer@drexelmed.edu.
² Department of Radiation Oncology, Christiana Care, 4701 Ogletown-Stanton Rd, Newark, DE 19713, USA.

PMID: 28576175
DOI: 10.1016/j.soc.2017.01.003

Abstract

Malignancies arising from the central nervous system are rare. Brain metastases, in contrast, are perhaps the most common neurologic complication of cancer. Radiotherapy, as part of combined modality therapy, continues to evolve with the advancement of stereotactic radiosurgery indications, the addition of new technologies, such as alternating electric field therapy, and mounting advances in the complex biology of these entities. The explosion of new clinical trials combined with newly discovered molecular markers suggest the beginning of a paradigm shift in the management of these challenging malignancies that will allow for future risk-stratification strategies.

Keywords: Brain metastases; Brain tumors; Glioblastoma.

Publication types

Review

MeSH terms

Brain Neoplasms / radiotherapy
Brain Neoplasms / secondary*
Brain Neoplasms / surgery
Brain Neoplasms / therapy*
Central Nervous System Neoplasms / radiotherapy*
Combined Modality Therapy
Humans
Neoplasm Metastasis / radiotherapy
Radiosurgery / instrumentation
Radiosurgery / trends*
Radiotherapy / trends*