Signature of the Sleeper Cell: A Biomarker of HIV Latency Revealed

Trends Immunol. 2017 Jul;38(7):457-458. doi: 10.1016/j.it.2017.04.007. Epub 2017 May 13.

Abstract

HIV establishes a reservoir in latently infected T cells, and this reservoir has long hampered curative approaches. A recent study by Descours et al. identifies CD32a as a marker of latently infected T cells, potentially opening the way to the development of strategies that directly target this critical HIV reservoir.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, N.I.H., Extramural
  • Comment

MeSH terms

  • Biomarkers / metabolism
  • CD4-Positive T-Lymphocytes / immunology
  • CD4-Positive T-Lymphocytes / virology*
  • Gene Expression
  • HIV Infections / genetics
  • HIV Infections / immunology
  • HIV Infections / therapy
  • HIV Infections / virology*
  • HIV-1 / pathogenicity
  • HIV-1 / physiology*
  • Humans
  • Molecular Targeted Therapy
  • RNA, Viral / genetics
  • RNA, Viral / immunology
  • Receptors, IgG / genetics*
  • Receptors, IgG / immunology
  • Virus Activation
  • Virus Latency*

Substances

  • Biomarkers
  • Fc gamma receptor IIA
  • RNA, Viral
  • Receptors, IgG