Heritability of plasma neopterin levels in the Old Order Amish

Uttam K Raheja; Dietmar Fuchs; Christopher A Lowry; Sarah H Stephens; Mary A Pavlovich; Hira Mohyuddin; Hassaan Yousufi; Kathleen A Ryan; Jeff O'Connell; Lisa A Brenner; Cecile Punzalan; Andrew J Hoisington; Gursharon K Nijjar; Maureen Groer; Alan R Shuldiner; Toni I Pollin; John W Stiller; Braxton D Mitchell; Teodor T Postolache

doi:10.1016/j.jneuroim.2017.02.016

Heritability of plasma neopterin levels in the Old Order Amish

J Neuroimmunol. 2017 Jun 15:307:37-41. doi: 10.1016/j.jneuroim.2017.02.016. Epub 2017 Feb 22.

Authors

Uttam K Raheja¹, Dietmar Fuchs², Christopher A Lowry³, Sarah H Stephens⁴, Mary A Pavlovich⁴, Hira Mohyuddin⁵, Hassaan Yousufi⁵, Kathleen A Ryan⁴, Jeff O'Connell⁴, Lisa A Brenner⁶, Cecile Punzalan⁷, Andrew J Hoisington⁸, Gursharon K Nijjar⁵, Maureen Groer⁹, Alan R Shuldiner⁴, Toni I Pollin⁴, John W Stiller¹⁰, Braxton D Mitchell¹¹, Teodor T Postolache¹²

Affiliations

¹ Mood and Anxiety Program, University of Maryland School of Medicine, 685 W. Baltimore Street, Suite# 930, Baltimore, MD 21201, USA; Child and Adolescent Psychiatry Residency Program, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 12 Executive Park Drive, Atlanta, GA 30329, USA.
² Division of Biological Chemistry, Biocenter, Innsbruck Medical University, Innrain 80, 6020, Innsbruck, Austria.
³ Rocky Mountain Mental Illness Research Education and Clinical Center (MIRECC), Veterans Integrated Service Network (VISN) 19, 1055 Clermont St, Denver, CO 80220, USA; Department of Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Campus, 13001 E 17th Pl, Aurora, CO 80045, USA; Military and Veteran Microbiome Consortium for Research and Education (MVM-CoRE), 1055 Clermont St, Denver, CO 80220, USA; Department of Integrative Physiology and Center for Neuroscience, University of Colorado Boulder, Boulder, CO 80309, USA; Center for Neuroscience, University of Colorado Anschutz Medical Campus, 13001 E 17th Pl, Aurora, CO 80045, USA.
⁴ Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, 685 W. Baltimore Street, Baltimore, MD 21201, USA; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, 685 W. Baltimore Street, Baltimore, MD 21201, USA.
⁵ Mood and Anxiety Program, University of Maryland School of Medicine, 685 W. Baltimore Street, Suite# 930, Baltimore, MD 21201, USA.
⁶ Rocky Mountain Mental Illness Research Education and Clinical Center (MIRECC), Veterans Integrated Service Network (VISN) 19, 1055 Clermont St, Denver, CO 80220, USA; Department of Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Campus, 13001 E 17th Pl, Aurora, CO 80045, USA; Military and Veteran Microbiome Consortium for Research and Education (MVM-CoRE), 1055 Clermont St, Denver, CO 80220, USA.
⁷ U.S. Food and Drug Administration, Center for Food Safety and Applied Nutrition Office of Analytics and Outreach, Division of Public Health Informatics and Analytics, 5001 Campus Drive, College Park, MD 20740, USA.
⁸ Military and Veteran Microbiome Consortium for Research and Education (MVM-CoRE), 1055 Clermont St, Denver, CO 80220, USA; Department of Civil and Environmental Engineering, US Air Force Academy, Colorado Springs, CO 80840, USA.
⁹ College of Nursing, University of South Florida, 4202 E Fowler Ave, Tampa, FL 33620, USA.
¹⁰ Mood and Anxiety Program, University of Maryland School of Medicine, 685 W. Baltimore Street, Suite# 930, Baltimore, MD 21201, USA; Department of Behavioral Health, St. Elizabeth's Hospital, 1100 Alabama Ave SE, Washington, DC 20032, USA.
¹¹ Division of Endocrinology, Diabetes and Nutrition, Department of Medicine, University of Maryland School of Medicine, 685 W. Baltimore Street, Baltimore, MD 21201, USA; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, 685 W. Baltimore Street, Baltimore, MD 21201, USA; Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, MD 20201, USA.
¹² Mood and Anxiety Program, University of Maryland School of Medicine, 685 W. Baltimore Street, Suite# 930, Baltimore, MD 21201, USA; Rocky Mountain Mental Illness Research Education and Clinical Center (MIRECC), Veterans Integrated Service Network (VISN) 19, 1055 Clermont St, Denver, CO 80220, USA; Military and Veteran Microbiome Consortium for Research and Education (MVM-CoRE), 1055 Clermont St, Denver, CO 80220, USA; Mental Illness Research, Education and Clinical Center (MIRECC), Veterans Integrated Service Network (VISN) 5, VA Capitol Health Care Network, 209 West Fayette Street, Baltimore, MD 21201, USA. Electronic address: tpostola@som.umaryland.edu.

PMID: 28495136
DOI: 10.1016/j.jneuroim.2017.02.016

Abstract

Background: We examined the heritability of neopterin, a biomarker for cell-mediated immunity and oxidative stress, and potentially for psychiatric disorders, in the Old Order Amish.

Methods: Plasma neopterin levels were determined in 2015 Old Order Amish adults. Quantitative genetic procedures were used to estimate heritability of neopterin.

Results: Heritability of log-neopterin was estimated at 0.07 after adjusting for age, gender, and household (p=0.03). The shared household effect was 0.06 (p<0.02).

Conclusions: We found a low heritability of neopterin and small household effect, suggesting that non-household environmental factors are more important determinants of variance of neopterin levels in the Amish.

Keywords: Biomarkers; Heritability; Neopterin; Old Order Amish; Psychiatric disorders.

MeSH terms

Adult
Aging / blood*
Aging / immunology
Amish / statistics & numerical data*
Environment
Female
Humans
Male
Middle Aged
Neopterin / blood*
Neopterin / genetics
Retrospective Studies

Substances

Neopterin

Grants and funding

U01 HL072515/HL/NHLBI NIH HHS/United States