GMP-ing to Spatial Conclusions about Emergency and Leukemic Myelopoiesis

Madeline Niederkorn; Daniel T Starczynowski

doi:10.1016/j.stem.2017.04.005

GMP-ing to Spatial Conclusions about Emergency and Leukemic Myelopoiesis

Cell Stem Cell. 2017 May 4;20(5):579-581. doi: 10.1016/j.stem.2017.04.005.

Authors

Madeline Niederkorn¹, Daniel T Starczynowski²

Affiliations

¹ Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.
² Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA. Electronic address: daniel.starczynowski@cchmc.org.

Abstract

Hematopoietic stem cells (HSCs) in the bone marrow (BM) form mature blood cells of all lineages through expansion of lineage-biased progenitors. In a recent issue of Nature, Hérault et al. (2017) uncover a unique spatiotemporal mechanism of granulocyte-macrophage progenitors (GMPs) employed in emergency hematopoiesis that is also hijacked in leukemia.

Publication types

Comment

MeSH terms

Cell Differentiation / physiology
Cell Proliferation / physiology
Granulocyte-Macrophage Progenitor Cells / cytology*
Hematopoiesis / physiology*
Hematopoietic Stem Cells / cytology*
Humans
Leukemia, Myeloid, Acute / metabolism*
Models, Biological
Myelopoiesis / physiology

Abstract

Publication types

MeSH terms

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