Interferon gamma does not induce antiviral resistance in T lymphocytes

M Zucca; G Gribaudo; B Ferrara; G Cavallo; S Landolfo

Interferon gamma does not induce antiviral resistance in T lymphocytes

J Biol Regul Homeost Agents. 1988 Jan-Mar;2(1):15-8.

Authors

M Zucca¹, G Gribaudo, B Ferrara, G Cavallo, S Landolfo

Affiliation

¹ Institute of Microbiology, University, Torino, Italy.

PMID: 2845724

Abstract

We compared the activity of human recombinant alpha and gamma interferons (IFNs) on normal T lymphocytes and various T cell lines. IFN gamma, unlike IFN alpha, did not promote the antiviral state in these cells, or induce the activity of 2'-5' oligoadenylate synthetase. The lack of antiviral effect was observed using an RNA virus (VSV) and a DNA virus (HSV, type 1) as challenger viruses.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

2',5'-Oligoadenylate Synthetase / metabolism
Blotting, Western
Humans
Interferon Type I / pharmacology*
Interferon-gamma / pharmacology*
Interleukin-2 / pharmacology
Recombinant Proteins
Simplexvirus
T-Lymphocytes / immunology*
Tumor Cells, Cultured
Vesicular stomatitis Indiana virus

Substances

Interferon Type I
Interleukin-2
Recombinant Proteins
Interferon-gamma
2',5'-Oligoadenylate Synthetase