The Immunogenicity of Fractional Intradermal Doses of the Inactivated Poliovirus Vaccine Is Associated With the Size of the Intradermal Fluid Bleb

Clin Infect Dis. 2017 Sep 1;65(5):851-854. doi: 10.1093/cid/cix381.

Abstract

The immunogenicity of fractional (one-fifth, 0.1 mL) intradermal doses of the inactivated poliovirus vaccine (ID fIPV) is positively correlated with the size of the intradermal fluid bleb. Training of vaccinators for campaign and routine ID fIPV administration should focus on generating an 8- to 10-mm bleb with each injection. Clinical Trials Registration NCT01847872.

Keywords: inactivated poliovirus vaccine; intradermal; polio.

Publication types

  • Clinical Trial, Phase IV
  • Randomized Controlled Trial

MeSH terms

  • Antibodies, Viral / blood
  • Blister / epidemiology
  • Blister / immunology*
  • Gambia
  • Humans
  • Infant
  • Injections, Intradermal / statistics & numerical data*
  • Poliovirus Vaccine, Inactivated / administration & dosage*
  • Poliovirus Vaccine, Inactivated / immunology*
  • Poliovirus Vaccine, Inactivated / therapeutic use
  • Seroepidemiologic Studies

Substances

  • Antibodies, Viral
  • Poliovirus Vaccine, Inactivated

Associated data

  • ClinicalTrials.gov/NCT01847872